Tropisetron is an α7 nicotinic partial agonist with superior effects to GTS-21, which was shown to enhance cognition in healthy people [1]. Additionally it is a 5-HT3 antagonist which have a long history of benefits to mental health. Acting synergistically, 5-HT3 antagonism prevents nausea induced by α7 nicotinic partial agonism, while simultaneously giving it a dual nootropic effect. α7 nicotinic receptor partial agonism is neuroprotective and non-addictive, with literature suggesting the cognition enhancement by nicotine may be owed to this receptor, without the euphoric effects. This receptor is also responsible for the anti-inflammatory effects of nicotine, and more selective agonists for a7 such as GTS-21 (or Tropisetron) are much stronger.